ABSTRACT
Tumor necrosis factor (TNF) and interferon gamma (IFN-γ) are pro-inflammatory and anti-inflammatory cytokine that is central to the development of autoimmune disease, cancer, and protection against infectious pathogens. A case-control study was conducted in the AL HUSSAIN Teaching General hospital in Thi-Qar governorate with a total of 190 individuals involved in the current study, 95 of them were infected with SARC COV 2, and 95 were healthy as control group. Serum was collected from each of them to assess the levels of The, TNFα, INFα, ferritin, D-dimer. TNF-α level increased significantly (P<0.05) (67, 50.6 and 15.25Pg/L), IFN-γ level significantly reduced (P<0.05) (21, 17 and 6.2IU/L), serum ferritin was significantly increased (P<0.05) (685.2, 395, and 87ng/ml). At the last one D dimer (1.7, 0.9 and 0.05mg/L) in the both patient groups (infected and non-infected) and healthy persons. The mean of TNFα, INFα concentration were higher in patients than control group (P<0.05). © 2021 Iranian Society of Ichthyology.
ABSTRACT
Objective: to determine the level of blood markers of cellular Human Cluster of Differentiation 147 (CD147) by ELISA assay. Immunological system, establishing the profile in patientsSARS-CoV-2 invades host cells via a novel route: CD147-spike protein. Methods: a case-control study including 30 patients (10 female) with SARS-CoV-2 repertory disorder whose follow-up was carried out at the outpatient clinic of the intensive care unit Service at Al Hussain Hospital, southern of Iraq, Patients were divided into three subgroups based on the onset of symptoms within the first 6 days of the acute phase of disease: subgroup A, subgroup B, and C. according to the type of drugs. Main systemic subgroup. Treatment group included 60 outpatients (25 female) being submitted to follow-up at the same hospital for non-inflammatory diseases. For determined the plasmatic levels of Human Cluster of Differentiation 147 (CD147), groups of S proteins Results: To start with, in vitro antiviral tests showed Meplazumab, infliximab and Etrolizumab an foe of CD147 adapted neutralizer, essentially hindered the infections from attacking host cells in comparison to controls, patients with presented concentrations of CD147 products (determined by plasmatic levels of S protein circulating in blood. Conclusion: our results indicate the presence of molecular SARS-CoV-2 invades respiratory cells determined by assay in patients which confirm a decrease in the defense capacity of the cellular system against toxicity induced by drugs in these patients. © 2020, Advanced Scientific Research. All rights reserved.